by /u/ZillaKami138 · 2024-04-16 05:57:00 in /d/Reviews
0 votes · 4 comments
- /u/ZillaKami138 22nd January, 2024 - 02:39 Yes, in theory. Alphafold is a generative AI that predicts protein folding and thus 3-d structure. I don't see why you couldn't use that or a similar program trained to predict biochemical properties of large globular proteins, smaller peptide fragments, or small molecules to identify species--known, unknown, or both--that bind to mew opioid receptors as full agonists but which have little to no kappa opioid receptor affinity, for example. Or predict new stimulants that can cross the blood-brain barrier and inhibit DAT and VMAT-2 with affinities similar to methamphetamine, but which have very little SERT activity. Smarter people than me can come up with more interesting and complex sets of interesting combinations of pharmacological properties--my knowledge med chem/pharmacology is rudimentary at best. But I fully expect such programs will become common place in big pharma soon as the primary tools for new drug discovery.
by /u/gemini · 2024-01-02 09:32:00 in /d/DrugManufacture
0 votes · 15 comments
- /u/ZillaKami138 8th January, 2024 - 21:37 I'm asking purely out of scientific curiosity, not because I want to go through the trouble of converting amphetamine salts into freebase. By the way, medical literature reports the pH of the stomach approximately vary between 1 and 2.5.
by /u/Leeds · 2024-01-03 08:10:00 in /d/DrugManufacture
0 votes · 9 comments
- /u/ZillaKami138 7th January, 2024 - 13:01 Can you explain why?
by /u/Leeds · 2024-01-03 08:10:00 in /d/DrugManufacture
0 votes · 9 comments
- /u/ZillaKami138 5th January, 2024 - 20:51 A substance being a hydrophobic freebase doesn't necessarily preclude it from human consumption. See crack and #3 heroin for examples. I don't know enough about amphetamine freebase's physical properties, e.g. boiling point, temperature it undergoes thermal decomposition, to say that it could be vaporized/smoked in similar fashion to crack or #3 H. However, I think it's entirely plausible that a freebase amphetamine oil could be smoked. The practicality of doing this is another matter...
by /u/Leeds · 2024-01-03 08:10:00 in /d/DrugManufacture
0 votes · 9 comments
- /u/ZillaKami138 13th April, 2023 - 23:04 Peruse /d/Opiates generally; see /post/186be076597cd7c9035a specifically.
by /u/porkrind · 2023-04-12 00:45:00 in /d/DNMSourcing
0 votes · 2 comments