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Does anyone know the best way to make an opiate nasal spray?
- /u/socat2me 13th April, 2023 - 20:32 As numberTwo mentioned, you first want to make sure that it's water soluble. Most CW has the active component present in hydrochloride salt form so it should be water soluble. Assuming that's the case you need to get a decent nasal spray pump / empty nasal spray bottle of course (the ones with clear containers are the best so that you can make sure everything is well dissolved, if your pump bottle isn't translucent you should make the nasal spray solution in a clear glass container and transfer it over after you've verified everything is dissolved well).

The other thing you need is an accurate way to measure liquids, such as a pipette or syringe (if you use a syringe, don't go larger than 3mL otherwise you will lose some accuracy).

Most nasal sprays are calibrated to where a single spray delivers a tenth of a mL (.1mL) aka ten sprays per mL. You should, however, verify this to be safe by filling it with a predetermined amount of water, let's say 3mL. Then count how many sprays it takes to empty it to make sure you get roughly 30 sprays (not counting the initial pumps required to prime the pump and get the spray started). If not 10 per mL figure out how much is delivered by the nasal spray by dividing number of sprays required to empty the spray by the number of mL you added. Substitute that number wherever you see a 10 below.

Now to make the spray you need to figure out how many micrograms or milligrams per spray you want. Assuming that the nasal spray delivers 10 sprays per mL you multiply that number by 10 and that's the concentration in mass per mL that you need.

NOTE: It's better to make the spray a bit weaker and where you need 3 or 4 pumps for a dose than it is to make it too strong, you don't want one pump to be the difference between a nod and an OD. Whatever your desired total dose to be delivered by the spray is, it's best to first divide that number by 3 or 4 and then multiply that by 10. That's the mass/mL concentration of the nasal spray solution that you want.

Example: Your usual dose of your CW is 12mg. First divide this number by 4 to get 3mg this is the dose per spray for the solution we're making. Multiply by 10 to get 30mg. The concentration of nasal spray that you want is 30mg/mL. In order to figure out the total amount you need to weigh out, multiply that concentration by the total amount of spray you want. You really need at a few mL of liquid in the spray in order to have the nasal spray work well. A lot of nasal sprays will only hold like 10mL though, so let's just assume 8mL of solution here.

8mL*30mg/mL = 240mg

Now to actually make the solution. Measure out the 240mg and add it to the nasal spray bottle. Get some distilled water and microwave it until it's fairly hot, not boiling but just hot to where it will dissolve the CW better. Use your liquid measuring device to measure out 8mL and add it to the 240mg of CW, shake/stir/agitate the solution until you see that everything has dissolved

Important note: If you make the concentration too high it might become saturated, there's a limit to how much of a substance you can dissolve in water so if your dosage is too high a nasal spray might not be efficient. For example, if you have to do 200mg to get high it will be tough to get a buzz off a nasal spray.

by /u/motleycruise · 2023-04-13 18:57:00 in /d/DrugManufacture

0 votes · 9 comments

how to make amphetamine from freebase help guys
- /u/socat2me 30th May, 2023 - 09:49 This is a fairly dangerous reaction that under no circumstances should you perform inside, but you need to bubble dry HCl acid through it while it's dissolved in a fairly nonpolar organic solvent, and it will precipitate out. The type of setup you are looking for is called a gas generator setup. If you look up "how to generate dry HCl gas" you will probably find plenty of methods, since it's used as a step in methamphetamine production.

This is an example⚠️ of one way to do it. On left there is 3-neck 250ml roundbottom flask, pressure equalized addition funnel, a 90 degree vacuum / gas adapter. Hose going from the 90 degree adapter to a glass pipette that's inserted into a thermometer adapter in another 3-neck, and has the end submerged into the liquid. You can also use what's called a gas-washing bottle for the glassware in the middle, it's much less to mess with. The thing on the right is an upside-down funnel gas trap, which traps any escaping vapors and neutralizes them.

In your case, the solution in the beaker on the right should be fairly concentrated sodium bicarbonate or sodium carbonate. In the middle you would put the organic solution of the a-oil with the gas bubbling into it, and on the left you would have HCl in the 3-neck round bottom with sulfuric acid dripping into it from the addition funnel.

Another, safer way would be to drip HCl from the addition funnel onto calcium chloride, I would suggest you use this method instead of working with sulfuric acid.

Also you should add an additional step between the left and middle, which is some kind of trap to prevent suck back into the 3-neck.

That should be enough to give you a decent start. Again, this is not a reaction to play around with since it generates HCl gas, but if you are going to do it I figure you should at least see an example of a setup that actually has a safety measure like the gas trap.

by /u/mr_pablitoescobar · 2023-05-26 21:35:00 in /d/DrugManufacture

0 votes · 2 comments

*USA* Purest domestic meth?
- /u/socat2me 18th May, 2022 - 14:42 lol yeah I did although it was around 4 or 5 months ago now. I had my suspicions for a long time but they were at odds with my subjective evaluation of the quality of the current meth compared to the stuff I used to get circa 2013 (which for some reason was like, ACS grade purity). That, and I knew all the cartels were using P2P, so I thought all this cartel meth must be racemic since the P2P + reductive amination synthesis gives a racemic product. I just wasn't aware until recently that they were also doing bulk enantiomer resolution with d-tartaric acid. That caused me to look into it more.

by /u/morlvob · 2022-03-19 18:56:00 in /d/DNMSourcing

0 votes · 8 comments

*USA* Purest domestic meth?
- /u/socat2me 20th March, 2022 - 15:42 Dude check out all the recent tests for methamphetamine on drugsdata.com. Honestly as long as they haven't done anything weird to it, everyone has more or less the same thing these days, everyone is just placebo-ing out like crazy and we've seen tons of examples proving it. It's amazing what a bit of sales talk and a price increase can do to convince people that they're taking something special.

All this meth all P2P cartel meth that's been resolved to have a high enantiomeric excess of d-meth using (L)-(+)-tartaric acid and crystallization and comes in at an average of like 97% purity.

The DEA puts out a big internal publication each year with tons of information on each specific drug called a national drug threat assessment, and it contains lots of debriefing info like where it's coming from, what the average purity seized at the border and on the streets is, etc. They determined that well over 95% of the meth coming into the US is all the same Sinaloa cartel stuff.

They've gotten really good at making the stuff and it's absolutely flooding in across the southern border. That's why it's so dirt cheap. It's an excess of supply, not because it's all just cut and crap and nobody has real stuff. Check drugsdata and try and compare the amount of meth samples that contained any active cuts to how many are just meth and inactive impurities..

If you check my post history I also came up with a method to test your meth to see whether it's d-meth or racemic (well, just whether it's racemic or either d or l meth, but if you had pure l meth that would be very bizarre) and it only requires a smartphone, polarized sunglasses, acetone, and a shotglass.

Don't get me wrong there can be a difference between the quality that vendors have. Some vendors will clean their stuff up to get out that few % of crap, or it'll come from a chemist who's better about the workup. And that extra few % can make a big deal if you're vaporizing, because those few percent impurities can really fuck up the vaporization, but if you're consuming meth orally then just pick a cheap vendor first and try their stuff out before you spring for some of this $75/g nonsense. If you did a blind test I doubt you'd be able to pick any one vendors stuff out from another's just by what eating 20mg does.

by /u/morlvob · 2022-03-19 18:56:00 in /d/DNMSourcing

0 votes · 8 comments

DONT BUY FROM SINALOA SICKNESS OR THIS WILL BE YOU
- /u/socat2me 27th October, 2023 - 19:20 Dude if you're not trolling you may have dangerously high levels of carbon monoxide wherever you're staying. Get a carbon monoxide detector. If you don't find anything abnormal then I recommend you seek medical attention.

by /u/ambientsmoke · 2023-10-27 15:19:00 in /d/rcsources

0 votes · 28 comments